中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (6): 397-399.doi: 10.12144/zgmfskin202606397

• 新发与再发感染性皮肤病 • 上一篇    下一篇

类鼻疽伯克霍尔德菌皮肤感染一例

邓哲宇1,杨浩1,周文哲1,于悦1,蒋欣雨2,吴玮1   

  1. 1广东医科大学附属医院皮肤科，广东湛江，524000；2广东医科大学第一临床医学院，广东湛江，524000
  • 出版日期:2026-06-15 发布日期:2026-06-04

Cutaneous infection caused by Burkholderia pseudomallei: a case report

DENG Zheyu1, YANG Hao1, ZHOU Wenzhe1, YU Yue1, JIANG Xinyu2, WU Wei1   

  1. 1 Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China; 2 First Clinical School of Medicine, Guangdong Medical University, Zhanjiang 524000, China
  • Online:2026-06-15 Published:2026-06-04

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摘要： 本文报道类鼻疽伯克霍尔德菌皮肤感染一例，并复习相关文献。患者，男，63岁，右足背皮肤增生3个月，右大腿疼痛性肿块1个月，经DNA-病原微生物宏基因组检测及细菌培养，诊断为皮肤类鼻疽伯克霍尔德菌感染，根据药敏结果给予头孢他啶、复方磺胺甲噁唑，局部脓肿切开引流治疗，皮损消退。文献复习显示，36例以皮肤为首要表现的类鼻疽伯克霍尔德菌感染患者中，无明显性别差异，下肢为最常见受累部位（52.8%），41.7%合并糖尿病，55.6%出现迁徙感染；以头孢他啶和复方磺胺甲噁唑为核心的抗菌治疗联合必要的外科干预，痊愈率达94.4%。

关键词: 类鼻疽伯克霍尔德菌, 皮肤-皮肤迁徙性脓肿, 皮肤类鼻疽病

Abstract: This article reports a case of cutaneous infection caused by Burkholderia pseudomallei and reviews the relevant literature. The patient was a 63-year-old male who presented with skin hyperplasia on the dorsum of the right foot for 3 months and a painful mass on the right thigh for 1 month. The diagnosis of cutaneous Burkholderia pseudomallei infection was confirmed by DNA-pathogen metagenomic detection and bacterial culture. According to the drug sensitivity results, ceftazidime and trimethoprim-sulfamethoxazole were administered, combined with incision and drainage of local abscesses, and the skin lesions subsided. Literature review showed that among 36 patients with Burkholderia pseudomallei infection presenting with skin manifestations as the primary symptom, there was no significant gender difference, the lower extremities were the most common affected site (52.8%), 41.7% were complicated with diabetes mellitus, and 55.6% developed migratory infection. Antibacterial therapy centered on ceftazidime and trimethoprim-sulfamethoxazole combined with necessary surgical intervention resulted in a cure rate of 94.4%.

Key words: Burkholderia pseudomallei, cutaneous-to-cutaneous metastatic abscess, cutaneous melioidosis