中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (11): 649-652.doi: 10.12144/zgmfskin202011649

• 论著 • 上一篇    下一篇

IL-33和IL1RL1基因单核苷酸多态性与特应性皮炎相关性研究

杨艳,陈荃,刘玉梅,周欣,田歆,高爱莉,熊斯颖,陈晓吟,李薇,朱慧兰   

  1. 广州市皮肤病防治所，广东广州，510095
  • 出版日期:2020-11-15 发布日期:2020-10-30
  • 通讯作者: 刘玉梅, E-mail: 1109180611@qq.com

Correlation between single nucleotide polymorphisms of IL-33/IL1RL1 genes and atopic dermatitis

YANG Yan, CHEN Quan, LIU Yumei, ZHOU Xin, TIAN Xin, GAO Aili, XIONG Siying, CHEN Xiaoyin, LI Wei, ZHU Huilan   

  1. Guangzhou Institute of Dermatology, Guangzhou 510095, China
  • Online:2020-11-15 Published:2020-10-30
  • Contact: LIU Yumei, E-mail: 1109180611@qq.com

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摘要： 目的：分析IL-33和IL1RL1基因单核苷酸多态性(SNPs)与特应性皮炎（AD）的相关性。方法：PCR-SSP方法检测89例AD患者和138名正常对照组受试者IL-33和IL1RL1编码基因的等位基因和基因型频率。结果：AD患者的IL-33 rs1800925 C等位基因的频率高于对照组，而T等位基因和rs764706552等位基因G低于对照组（均P＜0.001）。IL-33 rs1800925基因型CC和rs764706552基因型CG与AD显著正相关（均P＜0.001）。两组患者的IL1RL1基因的等位基因和基因型频率无明显差异（均P＞0.05）。结论：IL-33基因可能与AD的发病相关。

关键词: 特应性皮炎, IL-33基因, 单核苷酸多态性

Abstract: Objective: To analyze the association between the loci polymorphisms of IL-33, IL1RL1 gene and atopic dermatitis (AD). Methods: The allele and genotype frequencies of IL-33 and IL1RL1 encoding genes in 89 AD patients and 138 normal controls were detected by PCR-SSP. Results: The allele frequency of IL-33 gene rs1800925 C in the AD patients was higher than that in the controls. The allele frequencies of IL-33 gene rs1800925 T and rs764706552 G in the AD patients were lower than those in the controls (Ps<0.001). The CC and CG genotypes frequencies of IL-33 rs1800925 and rs764706552 were significantly positively correlated with AD (Ps<0.001). There was no significant difference in the frequencies of alleles and genotypes of IL1RL1 gene between the two groups (Ps>0.05). Conclusion: rs1800925 and rs764706552 SNPs of IL-33 gene may be associated with the development of AD.

Key words: atopic dermatitis, IL-33 gene, single nucleotide polymorphism