中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (11): 677-680.doi: 10.12144/zgmfskin202011677

• 病例报告 • 上一篇    下一篇

亲毛囊性蕈样肉芽肿一例

朱思曼,张芊,金秋子,兰宇贞,王文慧,张春雷   

  1. 北京大学第三医院皮肤科，北京，100191
  • 出版日期:2020-11-15 发布日期:2020-10-30
  • 通讯作者: 张春雷，E-mail: zhangchunleius@163.com

Folliculotropic mycosis fungoides: a case report

ZHU Siman, ZHANG Qian, JIN Qiuzi, LAN Yuzhen, WANG Wenhui, ZHANG Chunlei   

  1. Department of Dermatology, Peking University Third Hospital, Beijing 100191, China
  • Online:2020-11-15 Published:2020-10-30
  • Contact: ZHANG Chunlei, E-mail: zhangchunleius@163.com

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摘要： 患者，男，28岁。全身瘙痒11年，头颈、躯干及双上肢红色丘疹、斑块伴嗜酸粒细胞增多5年，脱发2年。外周嗜酸粒细胞计数11 088/μL。组织病理示：毛囊周围中等量单一核细胞浸润，以不典型淋巴细胞为主，并见散在嗜酸粒细胞。免疫组化染色示浸润细胞主要是CD4+细胞。TCR基因重排示TCRδ、TCRγ均阳性。诊断：亲毛囊性蕈样肉芽肿。给予重组人干扰素α-2b 肌注，阿维A、甲氨喋呤、泼尼松等口服，糖皮质激素软膏外用。治疗7周后皮损好转。

关键词: 蕈样肉芽肿, 亲毛囊性

Abstract: A 28-year-old male presented with pruritus all over his body for 11 years, red papules and plaques on head, neck, trunk and arms with peripheral eosinophilia for 5 years, and alopecia for 2 years. Peripheral blood eosinophilic cell count was 11088/μL. Histopathological findings showed a mixed perifollicular infiltration which was composed mainly of irregular-shaped atypical lymphocytes and scattered eosinophils. Immunohistochemical staining indicated that the majority of infiltrated lymphocytes were CD4+ lymphocytes. TCR gene rearrangement showed TCRδ and TCRγ were positive. The diagnosis of folliculotropic mycosis fungoides was made. The lesions were improved after 7 weeks' treatment of intramuscular injections of recombinant interferon α-2b, oral acitretin, methotrexate, prednisone and topical corticosteroids cream.

Key words: mycosis fungoides, folliculotropic