中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (5): 290-294.doi: 10.12144/zgmfskin202205290

• 论著 • 上一篇    下一篇

20例鱼刺伤肉芽肿临床、病理及分子生物学检测分析

吕晨,张帆,刘永霞,周桂芝,陈声利,卢宪梅,暴芳芳,孙乐乐,王猛,孙远航,刘红,孙勇虎,张福仁   

  1. 山东第一医科大学附属皮肤病医院（山东省皮肤病医院），山东省皮肤病性病防治研究所，济南，250022
  • 出版日期:2022-05-15 发布日期:2022-03-15
  • 通讯作者: 孙勇虎，E-mail：suohandong@126.com

Clinicopathological and molecular characteristics of 20 fish stab wound granulomas

LYU Chen, ZHANG Fan, LIU Yongxia, ZHOU Guizhi, CHEN Shengli, LU Xianmei, BAO Fangfang, SUN Lele, WANG Meng, SUN Yuanhang, LIU Hong, SUN Yonghu, ZHANG Furen   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Veneorology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2022-05-15 Published:2022-03-15
  • Contact: SUN Yonghu, E-mail: suohandong@126.com

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摘要： 目的：分析鱼刺伤肉芽肿患者的临床特点、病理及分子生物学检测情况。方法：对我院门诊确诊的20例鱼刺伤肉芽肿患者临床资料进行回顾性分析。结果：20例患者中16例（80%）患者发病前有外伤史且与水产品或水有接触，4例（20%）无明显诱因；所有患者皮损发生于上肢，17例患者单侧发病，3例双侧发病；临床表现以原发皮疹、浅表破溃或多发结节为主。20例患者病理组织检查者均提示感染性肉芽肿；TB-IGRA阳性率为70%。17例（85%）患者于治疗后6个月内痊愈，1例治疗10个月后痊愈，2例正在随访中。结论：本文中患者海分枝杆菌感染多与日常接触水产品有关；临床以单侧发病为主；TB-IGRA阳性检出率高。

关键词: 海分枝杆菌, 感染性肉芽肿, 鱼刺伤肉芽肿, 游泳池肉芽肿

Abstract: Objective: To analyze the characteristics of clinic, biopsy and biological detection in the patients with fish stab wound granulomas. Methods: The data of 20 patients with fish stab wound granulomas in our hospital were retrospectively analyzed. Results: 16 (80%) patients had a history of trauma and contact with aquatic products or water before the onset of the disease, and 4 (20%) patients had no obvious predisposing cause. All patients had skin lesions on the upper limb, and the lesions involved with one upper limb in 17 patients, involved both upper limbs in 3 patients. The mainly clinical feature was the primary rash, superficial breaching, or multiple nodules. Among the patients who underwent pathological examination, all of the results suggested an infectious granuloma. TB-IGRA was positive in 70% patients. 17 (85%) patients recovered within 6 months of treatment, 1 patient recovered by 10 months, and other 2 patients ware under follow-up. Conclusion: M.marinum infection of the skin is mostly associated with the patient's daily exposure to aquatic products in this study. Most lesions are mainly on the unilateral upper limb. The TB-IGRA positive  rate is high.

Key words: Mycobacterium marinum, infective granuloma, fish stab wound granuloma, swimming pool granuloma