中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (4): 303-307.doi: 10.12144/zgmfskin202504303

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JAK抑制剂在皮肤病领域的超说明书使用

赵安琪1,2,刘红1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2025-04-15 发布日期:2025-04-09

Off-label prescriptions of JAK inhibitor in dermatology

ZHAO Anqi1,2, LIU Hong1,2   

  1. 1 Hospital for Skin Diseases, Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2025-04-15 Published:2025-04-09

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摘要： JAK抑制剂最早被用于治疗骨髓纤维化和类风湿性关节炎，后其适应症逐渐扩大至皮肤病领域。目前我国已批准了JAK抑制剂治疗银屑病、斑秃、特应性皮炎、移植物抗宿主病等皮肤病。临床研究表明越来越多的自身免疫性和炎症性皮肤病对JAK抑制剂具有良好的反应性。我们总结了当前JAK抑制剂在皮肤病领域的超说明书使用相关的临床研究，旨在为临床医生提供参考。

关键词: JAK抑制剂, 超说明书使用, JAK-STAT通路

Abstract: Initially utilized in the treatment of myelofibrosis and rheumatoid arthritis, JAK inhibitor's indications were gradually expanded to dermatology. Up until now, JAK inhibitor has been approved for the treatment of psoriasis, alopecia areata, atopic dermatitis, graft-versus-host disease and other skin diseases in China. In fact, more and more autoimmune and inflammatory skin diseases have shown favorable response to JAK inhibitors in clinical studies. We summarized the current clinical research of JAK inhibitors' off-label prescriptions in dermatology, aiming to provide references for clinicians.

Key words: JAK inhibitor, off-label prescription, JAK-STAT signaling pathway