中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (7): 529-532.doi: 10.12144/zgmfskin202507529

• 综述 • 上一篇    下一篇

汗孔角化症治疗进展

白璐,朱才勇   

  1. 中国人民解放军陆军第八十集团军医院皮肤病科，山东潍坊，261031
  • 出版日期:2025-07-15 发布日期:2025-07-07

Progress in the treatment of porokeratosis

BAI Lu, ZHU Caiyong   

  1. Department of Dermatology, The Hospital of No.80 Group Amy of PLA, Weifang 261031, China
  • Online:2025-07-15 Published:2025-07-07

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摘要： 汗孔角化症典型的临床特征为中央萎缩、周围呈堤状隆起的斑疹或斑片,传统的治疗方法主要包括局部外用5-氟尿嘧啶、维A酸乳膏、咪喹莫特等，口服阿维A及异维A酸等。近年来研究发现局部外用胆固醇/他汀类药物、磷酸二酯酶4（PDE-4）抑制剂、系统使用生物制剂、JAK抑制剂等取得了良好的疗效。本文对汗孔角化症最新的治疗方法进行综述。

关键词: 汗孔角化症, 胆固醇/洛伐他汀, 生物制剂

Abstract: Porokeratosis (PK) is a keratinized skin disease characterized by central atrophy and peripheral raised patches or rashes. The traditional treatment methods mainly include topical application of 5-fluorouracil, tretinoin cream, imiquimod, etc., and oral administration of acitretin and isotretinoin, etc. In recent years, it has been found that topical cholesterol/statin drugs, PDE-4 inhibitors, and biological agents, JAK inhibitors have been applied in clinical treatment and achieved good therapeutic effects. This review summarizs the latest treatment methods for PK.

Key words: porokeratosis, cholesterol-lovastatin, biological agents