中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (7): 526-528.doi: 10.12144/zgmfskin202507526

• 病例报告 • 上一篇    下一篇

皮肤链格孢霉感染一例

王武悦1，2,王淑芬1，2,陈声利1，2,暴芳芳1，2,于功奇1，2,王娜1，2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2025-07-15 发布日期:2025-07-07

Skin infection with Alternaria: a case report

WANG Wuyue1，2, WANG Shufen1，2, CHEN Shengli1，2, BAO Fangfang1，2, YU Gongqi1,2, WANG Na1，2   

  1. 1 Dermatology Hospital of Shandong First Medical University, Jinan 250022, China；2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2025-07-15 Published:2025-07-07

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摘要： 本文报道一例皮肤链格孢霉感染，患者因慢性粒细胞白血病口服奥布替尼治疗2年，右下肢出现暗红色浸润性斑块、溃疡3个月。患者曾于当地医院口服及外用药物治疗（诊断及药物不详），未见明显好转，遂就诊于我院，初步诊断考虑坏疽性脓皮病，建议患者行病理检查，病理提示感染性肉芽肿，PAS染色真皮内见圆形孢子和菌丝，真菌镜检阳性，真菌培养链格孢霉生长，确诊为皮肤链格孢霉感染。给予伊曲康唑联合外用舍他康唑乳膏后治愈。

关键词: 链格孢霉, 皮肤感染

Abstract: This paper reports a case of skin infection with Alternaria. The patient had been treated with oral orelabrutinib for 2 years for chronic myeloid leukemia. He presented with dark red infiltrative plaques and ulcers appeared on the right lower limb for 3 months. The patient had been treated with oral and topical medications in a local hospital (specific diagnosis and medication are unknown), but there was no significant improvement, so he was treated in our hospital. The initial diagnosis was pyoderma gangrenosum, and the patient was recommended to undergo pathological examination. The pathology showed infectious granuloma, PAS staining showed round spores and hyphae in the dermis, fungal microscopy was positive, and fungal culture Alternaria grew, and the patient was diagnosed with skin Alternaria infection. The patient was cured after itraconazole combined with topical sertaconazole cream.

Key words: Alternaria, skin infection