中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (4): 205-209.doi: 10.12144/zgmfskin202204205

• 论著 • 上一篇    下一篇

脓肿分枝杆菌临床分离株药物敏感性初探

岳陈达1,岑蕊言1,杨伟江1,王利群1,罗杰夫1,黎敏2,鲁卫平2,雷霞1   

  1. 1陆军军医大学大坪医院（陆军特色医学中心）皮肤科，重庆，400042；
    2陆军军医大学大坪医院（陆军特色医学中心）检验科，重庆，400042
  • 出版日期:2022-04-15 发布日期:2022-02-09
  • 通讯作者: 雷霞，E-mail:leixia1979@sina.com

In vitro susceptibility of Mycobacterium abscessus in skin and soft tissue infection

YUE Chenda1, CEN Ruiyan1, YANG Weijiang1, WANG Liqun1, LUO Jiefu1, LI Min2, LU Weiping2, LEI Xia1   

  1. 1 Department of Dermatology, Daping Hospital, Army Medical University, Chongqing 400042, China;
    2 Department of Clinical Laboratory, Daping Hospital, Army Medical University, Chongqing 400042, China
  • Online:2022-04-15 Published:2022-02-09
  • Contact: LEI Xia,E-mail:leixia1979@sina.com

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摘要： 目的：分析脓肿分枝杆菌临床分离株对常用抗生素的体外药物敏感性。方法：临床菌株分离自2019年9月至2021年6月就诊于陆军军医大学大坪医院皮肤科的脓肿分枝杆菌皮肤软组织感染患者，用微量肉汤稀释法检测其对克拉霉素、阿奇霉素、阿米卡星、莫西沙星、环丙沙星、米诺环素、美罗培南、利奈唑胺、异烟肼、利福平、头孢西丁的最小抑菌浓度。以脓肿分枝杆菌标准菌株（ATCC19977）为对照株。结果：共收集11例脓肿分枝杆菌感染患者的菌株，脓肿分枝杆菌对克拉霉素、阿米卡星、利奈唑胺、头孢西丁、头孢美唑的敏感率100%， 对异烟肼、利福平、米诺环素的耐药率100%，对美罗培南和环丙沙星的耐药率为91.7%。结论：克拉霉素、阿米卡星、利奈唑胺、头孢西丁、头孢美唑可作为治疗皮肤脓肿分枝杆菌感染的首选用药。异烟肼、利福平、米诺环素、美罗培南、环丙沙星不建议用于治疗皮肤脓肿分枝杆菌感染。

关键词: 脓肿分枝杆菌, 抗生素, 最小抑菌浓度, 皮肤感染

Abstract: Objective: To analyze the susceptibility of Mycobacterium abscess isolated from skin and soft tissue infection in vitro. Methods: Strains isolated from clinical samples of patients with Mycobacterium abscessus in our hospital from September 2019 to June 2021. The minimum inhibitory concentrations of clarithromycin, azithromycin, amikacin, moxifloxacin, ciprofloxacin, minocycline, meropenem, linezolid, isoniazid, rifampicin and cefoxitin on the Mycobacterium abscessus were detected by microbroth dilution method. The standard strain of Mycobacterium abscessus (ATCC19977) were used as control. Results: Eleven strains were collected. Mycobacterium abscessus are sensitive to clarithromycin (100%), amikacin (100%), linezolid (100%), cefoxitin (100%) and cefmetazole (100%) . The drug resistance rate of Mycobacterium abscessus to isoniazide, rifampicin and minocycline was 100%, that to meropenem and ciprofloxacin was 91.7%. Conclusion: According to the result of drug sensitivity tests in vitro, clarithromycin, amikacin, linezolid cefoxitin and cefmetazole can be used as the first choice for the treatment of Mycobacterium abscessus infection of skin. Isoniazid, rifampicin, minocycline, meropenem and ciprofloxacin are not recommended for the treatment of Mycobacterium abscessus infection of skin.

Key words: Mycobacterium abscessus, antibiotics, minimum inhibitory concentration, cutaneous infection