中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (12): 719-721.doi: 10.12144/zgmfskin201912719

• 论著 • 上一篇    下一篇

紧密连接蛋白Claudin-1、7在日光性角化病和皮肤鳞状细胞癌中的表达

黄秋红，周吉文，赵丽欣，朱灵燕，潘永年   

  1. 苏州市吴江区中医医院皮肤科，江苏苏州，215200
  • 出版日期:2019-12-15 发布日期:2019-12-24
  • 通讯作者: 黄秋红，E-mail：huangqiuhong1111@126.com

Expression of Claudin-1 and Claudin-7 in actinic keratosis and squamocellular carcinoma

HUANG Qiuhong, ZHOU Jiwen, ZHAO Lixin, ZHU Lingyan, PAN Yongnian   

  1. Department of Dermatology，Wujiang Hospital of Traditional Chinese Medicine, Suzhou 215000，China
  • Online:2019-12-15 Published:2019-12-24
  • Contact: HUANG Qiuhong, E-mail: huangqiuhong1111@126.com

PDF (PC)

117

摘要： 目的：检测紧密连接蛋白Claudin-1、7在日光性角化病(AK)和皮肤鳞状细胞癌（SCC）中的表达水平。方法：收集2014年11月至2016年11月我院病理科AK和SCC组织标本各30例，选取癌旁正常皮肤组织30例作为对照组，采用免疫组化方法检测癌旁正常表皮、AK和SCC组织中Claudin-1、7蛋白的表达。结果：对照组、AK和SCC组织中Claudin-1蛋白细胞阳性率分别为100%，53.33%和13.33%，三组两两比较，差异均有统计学意义(Ps<0.05)。Claudin-7在癌旁正常表皮、AK和SCC组织中均呈阴性表达。结论：Claudin-1蛋白在癌旁正常表皮、AK和SCC组织中表达水平逐渐下降，Claudin-1蛋白表达下调可能与表皮肿瘤的恶性转化有关。

关键词: Claudin-1, Claduin-7, 日光性角化病, 鳞状细胞癌

Abstract: Objective: To detect the expression level of Claudin-1 and Claudin-7 in the lesions of actinic keratosis (AK) and squamocellular carcinoma（SCC）. Methods: The expression levels of Claudin-1 and Claudin-7 were detected by immunohistochemical method in the 30 normal tissues adjacent to cancer, 30 AK lesions, 30 SCC lesons in our hospital from November, 2014 to November, 2016. Results: In the samples of normal controls, AK and SCC, the positivity rates of Claudin-1 cells were 100%, 53.33% and 13.33% respectively, with significant differences among three groups (Ps<0.05). Claudin-7 was negatively expressed in normal skin tissues, AK and SCC. Conclusion: The expression level of Claudin-1 protein decreased gradually in the adjacent normal skin tissues, AK and SCC tissues, and the down-regulation of Claudin-1 protein expression may be related to the malignant transformation of epidermal tumors.

Key words: Claudin-1, Claudin-7, actinic keratosis, squamocellular carcinoma