中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (11): 658-662.doi: 10.12144/zgmfskin202011658

• 论著 • 上一篇    下一篇

Axin1、Gsk-3β和CD82在皮肤鳞状细胞癌中的表达

朝鲁门1,2,张士发2    

  1. 1锦州医科大学北部战区总医院研究生培养基地，辽宁沈阳，110016；
    2北部战区总医院皮肤科，沈阳，110016
  • 出版日期:2020-11-15 发布日期:2020-10-30
  • 通讯作者: 张士发，E-mail: zhangshifa_1963@126.com

Expression of Axin1, Gsk-3β and CD82 in cutaneous squamous cell carcinoma

CHAO Lumen1,2, ZHANG Shifa2    

  1. 1 Post Graduate Training Base of General Hospital of North Theater Command of  Jinzhou Medical University, Shenyang 110016, China; 
    2 General Hospital of North Theater Command, Shenyang 110016, China
  • Online:2020-11-15 Published:2020-10-30
  • Contact: ZHANG Shifa, E-mail：zhangshifa_1963@126.com

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摘要： 目的：检测Axin1、Gsk-3β和CD82蛋白在皮肤鳞癌中的表达。方法：40例皮肤鳞状细胞癌（cSCC）作为实验组，15例正常皮肤组织作为对照组，采用免疫组织化学方法检测Axin1、Gsk-3β和CD82在两组中的表达。结果：Axin1在正常皮肤、cSCC I级、II级、III级的阳性表达率分别为86.7%、66.7%、40.0%、10.0%，Gsk-3β分别为80.0%、73.3%、20.0%、20.0%，CD82阳性表达率分别为73.3%、60.0%、26.7%、10.0%。在cSCC中Axin1与Gsk-3β表达呈正相关（r=0.677，P＜0.05）。结论：Axin1、Gsk-3β和CD82可能与cSCC肿瘤发展有关。

关键词: 皮肤鳞状细胞癌, Axin1, Gsk-3β, CD82, 免疫组织化学

Abstract: Objective: To detect the expression of Axin1, Gsk-3β and CD82 proteins in cutaneous squamous cell carcinoma. Methods: The expression level of Axin1, Gsk-3β and CD82 in 40 cases with cutaneous squamous cell carcinoma (cSCC) and 15 normal skin tissues were detected by immunohistochemistry. Results: The positivity rates of Axin1 in the normal skin, and cSCC lesions with pathological grade I, grade II and grade III were 86.7%, 66.7%, 40.0% and 10.0%, respectively, while the positivity rates of Gsk-3β were 80.0%, 73.3%, 20.0% and 20.0%, The positivity rates of CD8 were 73.3%, 60.0%, 26.7% and 10.0%. There was a positive correlation between the expression level of Axin1 and Gsk-3β in cSCC (r=0.677, P<0.05). Conclusion: The expression of Axin1, Gsk-3β and CD82 in cSCC may be related to the development of CSCC.

Key words: cutaneous squamous cell carcinoma, Axin1, Gsk-3β, CD82, immunohistochemistry