中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (5): 276-279.doi: 10.12144/zgmfskin201905276

• 论著 • 上一篇    下一篇

Caveolin-1、Met蛋白在日光性角化病、鲍温病和皮肤鳞状细胞癌中的表达

魏云  吴丽娟  丁高中  冯雨苗  孙澜   

  1. 南京医科大学附属苏州市立医院东区皮肤科，江苏苏州，215000
  • 出版日期:2019-05-15 发布日期:2019-06-03
  • 通讯作者: 孙澜，E-mail：slszsy@126.com

Expression of caveolin-1 and Met protein in actinic keratosis, Bowen disease and cutaneous squamous cell carcinoma tissues

WEI Yun, WU Lijuan, DING Gaozhong, FENG Yumiao, SUN Lan   

  1. Department of Ultrasound, Suzhou Municipal Hospital, Nanjing Medical University, Suzhou 215001, China
  • Online:2019-05-15 Published:2019-06-03
  • Contact: SUN Lan, E-mail：slszsy@126.com

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摘要： 目的：检测Caveolin-1、Met蛋白在肿瘤边缘正常皮肤、日光性角化病、鲍温病和皮肤鳞状细胞癌组织中的表达情况。方法：通过免疫组化SP法，对肿瘤边缘正常皮肤、日光性角化病(Actinic keratosis，AK)、鲍温病(Bowen's Disease，BD)、皮肤鳞状细胞癌(cutaneous squamous cell carcinoma，cSCC)标本中Caveolin-1、Met进行检测。结果：Caveolin-1在正常皮肤、AK、BD、SCC中阳性率依次为16.7%、36.8%、52.9%、78.9%，四组间采用Kruskal-wallis H秩和检验，差异具有统计学意义(P<0.05)。Met在正常皮肤、AK、BD、SCC中阳性率依次为8.3%、26.3%、58.8%、84.2%，四组间采用Kruskal-wallis H秩和检验，P<0.05，差异具有统计学意义。在cSCC组中，Caveolin-1、Met阳性表达之间呈现正相关(r=0.484,P=0.036)。结论：Caveolin-1、Met在AK、BD和cSCC细胞中表达强度与恶性程度相关，且Caveolin-1、Met可能在cSCC发生、发展中具有协同作用。

关键词: 皮肤鳞状细胞癌, 日光性角化, 鲍温病, Caveolin-1, Met

Abstract: Objective: To detect the expressions of Caveolin-1 and Met in adjacent nonmalignant epithelial tissue, actinic keratosis (AK), Bowen disease (BD) and cutaneous squamous cell carcinoma (cSCC) tissues. Methods: The expressions of Caveolin-1 and Met in normal skin tissues, AK, BD and cSCC were detected by immunohistochemistry SP technique. Results: The positive expression rates of Caveolin-1 in normal skin tissues,AK, BD and cSCC were 16.7%, 36.8%, 52.9% and 78.9% respectively and that of Met were 8.3%, 26.3%, 58.8%, 84.2% respectively, with significant differences among four groups by Kruskal-wallis H Test (Ps<0.05). There was a positive correlation between the level Caveolin-1 and Met expression in cutaneous squamous cell carcinoma  (P<0.05). Conclusion: The positive expression rates of Caveolin-1 and Met in four groups showed a gradual increased trend as the grade malignancy of normal skin,  AK, BD and cSCC and there may be a synergism between Caveolin-1 and Met in the development of cSCC. 

Key words: cutaneous squamous cell carcinoma, actinic keratosis, bowen disease, caveolin-1, Met