中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (11): 691-695.doi: 10.12144/zgmfskin202111691

• 论著 • 上一篇    下一篇

长脉冲1064 nm Nd:YAG激光联合外用抗真菌药治疗甲真菌病疗效的Meta分析

姚越1,郭姝婧1,李业贤1,程毅2,张国强1，2   

  1. 1河北医科大学第一医院皮肤科，石家庄，050031；
    2河北医科大学第四医院皮肤科，石家庄，050000
  • 出版日期:2021-11-15 发布日期:2021-09-13
  • 通讯作者: 张国强，E-mail: zgq810328@sina.com

Meta analysis: efficacy of long-pulsed 1064nm Nd:YAG laser combined with topical antifungal agents in the treatment of onychomycosis

YAO Yue1, GUO Shujing1, LI Yexian1, CHENG Yi2, ZHANG Guoqiang1,2   

  1. 1 Department of Dermatology, the First Hospital of Hebei Medical University, Shijiazhuang 050031, China; 
    2 Department of Dermatology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Online:2021-11-15 Published:2021-09-13
  • Contact: ZHANG Guoqiang, E-mail: zgq810328@sina.com

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摘要： 目的：通过Meta分析方法评价长脉冲1064 nm Nd:YAG激光联合外用抗真菌药治疗甲真菌病的疗效。方法：搜集PubMed、Web of Science、Sinomed、FMRS、知网、中国生物医学文献数据库、维普和万方数据库自建库至2021年3月1日收纳的长脉冲1064 nm Nd:YAG激光联合外用抗真菌药治疗甲真菌病的随机对照试验，统计软件采用Rev Man5.3和Stata11.0。结果：共纳入6项随机对照试验，353个病例。与单一激光治疗相比，长脉冲1064 nmNd:YAG激光联合外用抗真菌药物具有更高的临床有效率（OR=1.49，95%CI 1.04~2.12，Z=2.20，P=0.03）和真菌学清除率（OR=1.85，95%CI 1.21~2.82，Z=2.86，P=0.004），且复发率低（OR =0.23，95%CI 0.08~0.70，Z=2.59，P=0.010）。 结论：长脉冲1064 nm Nd:YAG激光联合外用抗真菌药是治疗甲真菌病的有效手段。

关键词: 甲真菌病, 长脉冲1064 nm Nd:YAG激光, 外用抗真菌药, Meta分析

Abstract: Objective: To evaluate the efficacy of long-pulsed 1064nm Nd: YAG laser combined with topical antifungal agents in the treatment of onychomycosis by meta-analysis. Methods: Randomized controlled trials of long-pulsed 1064nm Nd:YAG laser combined with topical antifungal agents in the treatment of onychomycosis were collected in PubMed, Web of Science, Sinomed, FMRS, CNKI, CBM, VIP and Wanfang Database from inception to March 1st, 2021. Rev Man5.3 and Stata11.0 were used as statistical software. Results: Six randomized controlled trials with 353 patients were included in total. Compared with single laser treatment, long-pulse 1064 nmNd:YAG laser combined with topical antifungal agents had higher clinical response rates (OR=1.49, 95%CI 1.04~2.12, Z=2.20, P=0.03) and mycological clearance rates (OR=1.85, 95%CI 1.21~2.82, Z=2.86, P=0.004), and the recurrence rates were lower (OR=0.23, 95% CI 0.08~0.70, Z=2.59, P=0.010). Conclusion: The treatment of long-pulsed 1064nm Nd: YAG laser combined with topical antifungal drugs is effective in the treatment of onychomycosis.

Key words: onychomycosis, long-pulsed 1064nm Nd: YAG laser, topical antifungal agents, meta-analysis