中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (3): 179-181.doi: 10.12144/zgmfskin202003179

• 临床研究 • 上一篇    下一篇

CO2点阵激光联合萘替芬酮康唑乳膏治疗甲真菌病疗效评价

全小荣,李江辉,唐慧芬,张力,蒋军荣,蔡丽萍   

  1. 桂林市皮肤病医院皮肤科，广西桂林，541002
  • 出版日期:2020-03-15 发布日期:2020-03-30
  • 通讯作者: 全小荣，E-mail: Q4476@126.com

Clinical efficacy of carbon-dioxide fractional laser combined with naftifene ketoconazole cream in the treatment of onychomycosis

QUAN Xiaorong, LI Jianghui, TANG Huifen, ZHANG Li, JIANG Junrong, CAI Lipin   

  1. Department of Dermatology, Guilin Dermatology Hospital, Guilin 541002, China
  • Online:2020-03-15 Published:2020-03-30
  • Contact: QUAN Xiaorong, E-mail: Q4476@126.com

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摘要： 目的：评价CO2点阵激光联合萘替芬酮康唑乳膏外用治疗甲真菌病的临床疗效。方法：对2017年1月至2018年8月我科门诊甲真菌病患者患甲进行CO2点阵激光照射（2周1次），每日外涂萘替芬酮康唑乳膏治疗，共治疗16周。观察临床疗效、真菌学检查结果及不良反应发生情况。结果：共治疗35例患者，35个靶甲，其中指甲5个，趾甲30个；白色浅表型8个，远端侧位甲下型18个，近端甲下型9个。在第4次治疗后有效率为54.29%，真菌清除率为74.29%；疗程结束3个月后有效率为82.89%，真菌清除率为88.57%。结论：CO2点阵激光联合萘替芬酮康唑乳膏治疗甲真菌病安全有效。

关键词: CO2点阵激光, 萘替芬酮康唑, 甲真菌病

Abstract:

Objective: To assess the clinical efficacy of carbon-dioxide fractional laser combined with naftifene ketoconazole cream in the treatment of onychomycosis. Methods: The onychomycosis patients from Jan, 2017 to Aug, 2018 were treated with CO2 fractional laser once every 2 weeks and topical naftifene ketoconazole cream everyday for 16 weeks. The efficacy, fungal clearance rate and side effects of every patients were assessed. Results: Thirty-five patients with 35 nails, including 5 fingernails and 30 were treated. Of 35 nails, 8 were superficial white onychomycosis, 18 were distal and lateral subungual onychomycosis, and 9 were proximal subungual onychomycosis. The efficiency and fungal clearance rate were 54.29% and 74.29% after treatment for 4 times, while the efficiency and fungal clearance rate were 82.89% and 88.57% at the third month after the end of treatment. Conclusion: CO2 fractional laser combined with naftifene ketoconazole cream is effective and safe in treating onchomycosis.

Key words: CO2 fractional laser, naftifene ketoconazole, onychomycosis