中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (2): 75-79.doi: 10.12144/zgmfskin202002075

• 论著 • 上一篇    下一篇

富血小板血浆联合CO2点阵激光治疗萎缩性痤疮瘢痕疗效和安全性Meta分析

庄化迪1,冯杰2,刘顺英2,曾润鑫2,宋锦渲2,赵菊花1，3   

  1. 1西南医科大学临床医学院，四川泸州，646000；2川北医学院临床医学院，四川南充，637000；3南充市中心医院皮肤科，四川南充，637000
  • 出版日期:2020-02-15 发布日期:2020-03-18
  • 通讯作者: 赵菊花, E-mail: 214104642@qq.com

Meta analysis of efficacy and safety of platelet-rich plasma combined with fractional CO2 laser treatment for atrophic acne scar

ZHUANG Huadi1, FENG Jie2, LIU Shunying2, ZENG Runxin2, SONG Jinxuan2, ZHAO Juhua1,3   

  1. 1 Southwest Medical University Clinical Medical College, Luzhou 646000, China; 2 North Sichuan Medical College Clinical Medical College, Nanchong 637000, China; 3 Department of Dermatology,Nanchong Central Hospital, Nanchong 637000, China
  • Online:2020-02-15 Published:2020-03-18
  • Contact: ZHAO Juhua, E-mail: 214104642@qq.com

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摘要： 目的：系统评价富血小板血浆联合CO2点阵激光治疗面部萎缩性痤疮瘢痕的有效性及安全性。方法：检索从建库到2019年7月Cochrane Library、Embase、Medline、中国知网、万方数据库及维普数据库中富血小板血浆联合CO2点阵激光治疗面部萎缩性痤疮瘢痕的随机对照试验，筛选符合要求的文献并根据Cochrane偏倚风险评估方法评价纳入文献质量， 采用Revman5.3软件进行Meta分析。结果：最终纳入5个RCTs和Meta分析，结果显示：①联合疗法的总有效率和治愈率均高于单用激光组（P=0.008，0.0002）；②联合疗法和单用激光组的红斑、水肿持续时间及疼痛评分无统计学差异（P=0.21，0.35，0.50）。结论：富血小板血浆联合CO2点阵激光治疗萎缩性痤疮瘢痕的疗效优于单独使用CO2点阵激光，不良反应无明显差异。

关键词: 富血小板血浆, CO2点阵激光, 萎缩性痤疮瘢痕, Meta分析

Abstract: Objective: To evaluate the efficacy and safety of platelet-rich plasma combined with fractional CO2 laser in the treatment of facial atrophic acne scar. Methods: The related randomized controlled clinical trails of platelet-rich plasma combined with fractional CO2 laser for facial atrophic acne scars from Cochrane Library, Embase, Medline, CNKI, Wanfang and VIP were searched from the date of establishment to July 2019. The trails were evaluated according to Cochrane system evaluation method. Revman 5.3 software was used for meta-analysis. Results: Five RCTs were included. Meta analysis showed that the total effective rate and cure rate of combined therapy were higher than those of laser alone group (P=0.008，0.0002) and there was no significant difference in erythema, edema duration and pain score between combined therapy and laser alone (P=0.21，0.35，0.50). Conclusion: The efficacy rate of platelet-rich plasma combined with fractional CO2 laser treatment for atrophic acne scar is higher than that of laser only and there is no statistical difference in adverse reactions.

Key words: plasma, fractional CO2 laser, atrophic acne scar, Meta-analysis