中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (3): 142-146.doi: 10.12144/zgmfskin202003142

• 论著 • 上一篇    下一篇

白细胞介素17与慢性荨麻疹相关性的Meta分析

周博洋,柳舟,林励,李邻峰   

  1. 首都医科大学附属北京友谊医院皮肤科，北京，100050
  • 出版日期:2020-03-15 发布日期:2020-03-30
  • 通讯作者: 李邻峰，E-mail: zoonli@sina.com

Association between interleukin-17 and chronic urticaria: a meta-analysis

ZHOU Boyang, LIU Zhou, LIN Li, LI Linfeng   

  1. Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
  • Online:2020-03-15 Published:2020-03-30
  • Contact: LI Linfeng, E-mail: zoonli@sina.com

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摘要： 目的：系统评价白细胞介素17（Interleukin-17, IL-17）与慢性荨麻疹的相关性。方法：检索中国知网、万方数字化期刊全文数据库、VIP中国科技期刊全文数据库、中国生物医学文献数据库、PubMed、Cochrane Library、Web of Science等数据库，搜集有关IL-17与慢性荨麻疹相关的病例对照研究。时间范围为各数据库建库至2019年12月31日。由2名独立评价者进行文献筛选、资料提取和纳入研究偏倚风险评价，后采用Cochrance协作网提供的RevMan5.3软件进行Meta分析。结果：共纳入11个研究，其中慢性荨麻疹患者617例，对照组522例。Meta分析结果显示，慢性荨麻疹组患者血清中IL-17浓度明显升高，与对照组相比，差异具有统计学意义［SMD=1.52, 95%CI(1.13,1.91), Z=7.64, P<0.00001］。结论：慢性荨麻疹患者血清中IL-17明显升高，IL-17可能与慢性荨麻疹具有相关性。

关键词: 白细胞介素17, 慢性荨麻疹, 纽卡斯尔-渥太华量表, Meta分析

Abstract: Objective: To systematically evaluate the association between Interleukin-17 (IL-17) and chronic urticaria. Methods: The case-control studies on IL-17 and chronic urticaria were searched in CNKI, Wanfang Database, CQVIP, Sinomed Database, PubMed, Cochrane Library, Web of Science from inception to December 31, 2019. Two reviewers screened literature, extracted data, and assessed risk bias of included researches. Meta-analysis was performed by RevMan 5.3 software. Results: A total of 11 studies were included, including 617 patients with chronic urticaria and 522 controls. The results of meta-analysis showed that IL-17 level in the chronic urticaria group was significantly higher than that in the control group, with a significant difference ［SMD=1.52, 95%CI (1.13,1.91), Z=7.64, P<0.00001］. Conclusion: The level of IL-17 is elevated in the patients with chronic urticaria, and IL-17 may be associated with chronic urticaria.

Key words: Interleukin-17, chronic urticaria, Newcastle-Ottawa Scale, meta-analysis