中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (1): 8-13.doi: 10.12144/zgmfskin202201008

• 论著 • 上一篇    下一篇

银屑病和银屑病关节炎与溃疡性结肠炎相关性Meta分析

刘承灵1,贺赞1,任丹1,王婧宇1,杜治民1,孙玉发2,赵华1   

  1. 1解放军总医院第一医学中心皮肤科，北京，100089；
    2中央军委联合参谋部警卫局卫生保健处，北京，100017
  • 出版日期:2022-01-15 发布日期:2021-11-01
  • 通讯作者: 赵华，E-mail:luckhua301@163.com； 孙玉发，E-mail:dafa20136725@163.com

Association of psoriasis and psoriatic arthritis with ulcerative colitis: a meta-analysis

LIU Chengling1, HE Zan1, REN Dan1, WANG Jingyu1, DU Zhimin1, SUN Yufa2, ZHAO Hua1   

  1. 1 Department of Dermatology, the First Medical Center, PLA General Hospital, Beijing 100089, China;
    2 Health Service Department of the Guard Bureau of the Joint Staff Department, Beijing 100017, China
  • Online:2022-01-15 Published:2021-11-01
  • Contact: ZHAO Hua, E-mail:luckhua301@163.com; SUN Yufa, E-mail:dafa20136725@163.com

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摘要： 目的：有研究报道银屑病或银屑病关节炎患者溃疡性结肠炎发生率明显高于正常人，本文目的在于进一步明确银屑病、银屑病关节炎与溃疡性结肠炎的相关性。方法：通过Pubmed、Cochrane Library、Embase、知网、万方等数据库检索银屑病、银屑病关节炎并溃疡性结肠炎相关文献，采用Review Manager 5.3软件进行Meta分析。结果：共纳入13篇文献，横断面研究3篇、病例对照研究2篇、队列研究8篇，包含银屑病723 402例，银屑病关节炎37 059例，Meta分析结果显示银屑病与溃疡性结肠炎［RR=1.65(95% CI 1.55~1.76)，OR=1.76(95% CI 1.43~2.17)］,差异具有统计学意义，银屑病关节炎与溃疡性结肠［RR=2.14 (95% CI 1.72~2.66),OR=2.05 (95% CI 1.50~2.80)］,差异具有统计学意义。结论：银屑病、银屑病关节炎可能增加溃疡性结肠炎的发生率。

关键词: 银屑病, 银屑病关节炎, 溃疡性结肠炎, Meta分析

Abstract: Objective: Studies have reported that the incidence of ulcerative colitis in patients with psoriasis or psoriatic arthritis is significantly higher than that in normals. To determine the association between psoriasis, psoriatic arthritis patients and ulcerative colitis is the purpose of this article. Methods:The studies of psoriasis, psoriatic arthritis and ulcerative colitis in Pubmed, Cochrane Library, Embase , CNKI and Wanfang were searched and meta-analysis by Review Manager 5.3 software was performed. Results: A total of 13 articles, including 3 cross-sectional studies, 2 case-control studies and 4 cohort studies with 723 402 psoriasis patients and 37 059 psoriatic arthritis patients were analyzed. The results revealed that there was a correlation between psoriasis or psoriatic arthritis and ulcerative colitis ［RR=1.65 (95% CI 1.55-1.76), OR=1.76 (95% CI 1.43-2.17)］, ［RR=2.14 (95% CI 1.72-2.66), OR=2.05(95% CI 1.50-2.80)］. Conclusion: Psoriasis and psoriatic arthritis may increase the incidence of ulcerative colitis.

Key words: psoriasis, psoriatic arthritis, ulcerative colitis, meta-analysis