中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (4): 208-211.doi: 10.12144/zgmfskin202104208

• 论著 • 上一篇    下一篇

大疱性类天疱疮与恶性肿瘤相关性meta分析

李云1,朱庆焕2,廖奇峯3,杨猛2，4,黄耀辉4,潘延斌4,李建民4   

  1. 1陆军军医大学第一附属医院皮肤科，重庆，400038;2昆明医科大学第二附属医院皮肤科，昆明，650000;3安徽医科大学第一医院皮肤科，合肥，230032;4广西医科大学第三附属医院皮肤科，南宁，530031
  • 出版日期:2021-04-15 发布日期:2021-04-07
  • 通讯作者: 杨猛，E-mail: ymcomcn@126.com

Meta-analysis of the association of bullous pemphigoid with malignancy

LI Yun1, ZHU Qinghuan2, LIAO Chifeng3, YANG Meng2,4, HUANG Yaohui4, PAN Yanbin4, LI Jianmin4   

  1. 1 Department of Dermatology, The First Affiliated Hospital of the Army Medical University, Chongqing 400038, China; 2 Department of Dermatology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China; 3 Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei 230032, China; 4 Department of Dermatology, The Third Affiliated Hospital of Guangxi Medical University, Nanning 530031, China
  • Online:2021-04-15 Published:2021-04-07
  • Contact: YANG Meng, E-mail: ymcomcn@126.com

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摘要： 目的：明确大疱性类天疱疮(BP)与恶性肿瘤的相关性。方法：通过PubMed、Embase、Cochrane Central、CBM、CNKI、万方和VIP数据库检索大疱性类天疱疮（BP）并恶性肿瘤相关文献，采用Stata 12.0软件进行统计分析。结果：初步检索到1549篇文献，最终纳入10个病例对照研究，其中BP组2507例，对照组11808例。结果显示，与对照组相比，BP组恶性肿瘤总发生风险和血液恶性肿瘤发生风险高于对照组(均P<0.05)，两组实体恶性肿瘤发生风险无明显差异（P=0.07)。结论：BP和恶性肿瘤之间存在相关性，但需要更多的前瞻性研究来确认。

关键词: 大疱性类天疱疮, 血液恶性肿瘤, 实体恶性肿瘤, meta分析

Abstract: Objective: To determine the association of bullous pemphigoid (BP) with malignancy. Methods: The studies of BP and malignancy in Cochrane Library, PubMed, Embase, Wanfang, CNKI, and VIP database were searched. Meta-analysis was carried out by Stata 12.0 software. Results: A total of 1549 studies were initially searched, in which 10 randomized controlled trial were analyzed. The results showed that the risk of total malignancy and hematologic malignancy in the BP group were higher than that in the control group (Ps<0.05), but there was no significant difference in the incidence of solid malignancy between the two groups (P=0.07). Conclusion: There is an association between BP and malignancy, but more prospective studies are needed to confirm the association.

Key words: BP, hematologic malignancy, solid malignancy, meta analysis