关键词: 大疱性类天疱疮, 细胞因子信号传导抑制蛋白1, 细胞因子信号传导抑制蛋白3

Abstract: Objective: To detect the expression levels of suppressor of cytokine signaling 1 (SOCS-1) and suppressor of cytokine signaling 3 (SOCS-3) in the serum and bullous fluid of the patients with bullous pemphigoid (BP). Methods: The patients with BP diagnosed in our hospital from January 2017 to December 2018 and the patients with second degree scald used as controls were collected. The expression levels of SOCS-1 and SOCS-3 in the serum and blister fluid of the patients and controls group were detected by EILSA and the severity of BP was assessed through autoimmune blister severity score (ABSIS). The relationship between the expressions of SOCS-1 and SOCS-3 and between the levels of SOCS-1 or SOCS-3 and ABSIS were analyzed by Pearson correlation analysis. Results: Fouty-two patients and 30 patients were collected. The expression levels of SOCS-1 and SOCS-3 in the patients serum were 62.14±12.45 and 47.23±10.72, which were significantly higher than those in the control group (31.25±9.85 and 20.62±9.06) (Ps<0.05). The expression levels of SOCS-1 and SOCS-3 in the patients blister fluid were 106.45±30.27 and 91.42±24.58, which were significantly higher than those in the control group 67.26±21.33 and 51.07±15.16 (P＜0.05). SOCS-1 level was positively correlated with SOCS-3 level in the BP patients (P<0.05). The levels of SOCS-1 and SOCS-3 were positively correlated with ABSIS score respectively (P<0.05). Conclusion: The expression levels of SOCS-1 and SOCS-3 in serum and blister fluid of patients with bullous pemphigoid are up-regulated. The expression levels of SOCS-1 and SOCS-3 are positively correlated with ABSIS scores, which may be associated to the pathogenesis of BP. 

Key words: bullous pemphigoid, SOCS-1, SOCS-3