pembrolizumab,bullous pemphigoid ,"/> PD-1抑制剂诱发大疱性类天疱疮一例

中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (5): 364-366.doi: 10.12144/zgmfskin202305364

• 病例报告 • 上一篇    下一篇

PD-1抑制剂诱发大疱性类天疱疮一例

柳文红,俞韶华,亢婷,袁媛,张任娟,杜华,何春峰   

  1. 甘肃省中心医院（甘肃省妇幼保健院）皮肤科，甘肃兰州，730070
  • 出版日期:2023-05-15 发布日期:2023-05-16

Bullous pemphigoid induced by multiple tumors was treated with PD-1 inhibitor: a case report

LIU Wenhong, YU Shaohua, KANG Ting, YUAN Yuan, ZHANG Renjuan, DU Hua, HE Chunfeng   

  1. Department of Dermatology，Gansu Provincial Certral Hospital（Gansu Provincial Maternal and Child Health Hospital）, Lanzhou 730070, China
  • Online:2023-05-15 Published:2023-05-16

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摘要： 患者，女，54岁。周身红斑、水疱伴痒20天。既往“右侧结肠癌”术后并发全身多部位转移14年，近2年内间断使用帕博丽珠单抗治疗，皮肤科检查：全身散在分布绿豆至蚕豆大水疱，部分融合成大疱。组织病理示：表皮轻度角化，基底层下水疱形成，水疱内较多嗜酸粒细胞、中性粒细胞、单一核细胞浸润。免疫荧光: 基底膜带IgG、C3呈线状沉积。诊断:大疱性类天疱疮。

关键词: 帕博丽珠单抗, 大疱性类天疱疮

Abstract: A 54-year-old female presented with erythema, vesicles and itching for 20 days. It has been 14 years since the operation of “right colon cancer” complicated with multiple systemic metastases. In the past 2 years, intermittent treatment of Pablizumab was used. Dermatology showed mung bean to broad bean blisters scattered throughout the body, some fused to huge blisters. Pathology showed that the epidermis slightly keratinized, and the blister formed under the basal layer and there were more eosinophils, neutrophils and mononuclear cells in the blister. Immunofluorescence showed that IgG and C3 were linearly deposited in the basement membrane. The diagnosis of bullous pemphigoid was made.

Key words: pembrolizumab')">

pembrolizumab, bullous pemphigoid