中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (3): 185-188.doi: 10.12144/zgmfskin202203185

• 病例报告 • 上一篇    下一篇

利妥昔单抗联合糖皮质激素治疗难治性大疱性类天疱疮一例

陈雪1,谭城1,单敏洁1,闵仲生1,吉津1,陈芳1,刘青1,吴皞2,潘永正1   

  1. 1南京中医药大学附属医院皮肤科，江苏南京，210029；
    2南京医科大学附属江宁医院肿瘤科，江苏南京，210000
  • 出版日期:2022-03-15 发布日期:2022-01-05
  • 通讯作者: 潘永正，E-mail: drpanyz@163.com

Rituximab combined with glucocorticoid in the treatment of refractory bullous pemphigoid: a case report

CHEN Xue1, TAN Cheng1, SHAN Minjie1, MIN Zhongsheng1, JI Jin1, CHEN Fang1, LIU Qing1, WU Hao2, PAN Yongzheng1   

  1. 1.Department of Dermatology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210029,China;
    2.Department of Oncology, the Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 210000,China
  • Online:2022-03-15 Published:2022-01-05
  • Contact: PAN Yongzheng, E-mail: drpanyz@163.com

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摘要： 患者，男，35岁。四肢红斑、丘疹、水疱1个月。行皮肤组织病理、直接、间接免疫荧光及盐裂试验，符合大疱性类天疱疮诊断。予系统运用糖皮质激素，环磷酰胺冲击，联合吗替麦考酚酯、沙利度胺、静注人免疫球蛋白等治疗，疗效欠佳，改用利妥昔单抗联合糖皮质激素治疗后，病情好转。

关键词: 大疱性类天疱疮, 利妥昔单抗, 难治性, 溃疡性结肠炎

Abstract: A 35-year-old male presented with erythema, papules and blisters on the lower extremitie for 1 month. The features of pathology, direct and indirect immunofluorescence and salt cracking test were in accordance with bullous pemphigoid. The efficacy of glucocorticoid, cyclophosphamide, combined with mycophenolate mofetil, thalidomide and intravenous injection of human immunoglobulin was poor. The lesions subsided after treated with rituximab injection combined glucocorticoid.

Key words: bullous pemphigoid, rituximab, refractory, ulcerative colitis