中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (12): 764-768.doi: 10.12144/zgmfskin202012764

• 综述 • 上一篇    

生物制剂和生物技术治疗天疱疮进展

孙菲菲,杨宝琦   

  1. 山东第一医科大学附属皮肤病医院（山东省皮肤病医院），山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2020-12-15 发布日期:2020-12-04
  • 通讯作者: 杨宝琦，E-mail: baoqiyang@126.com

Update of biological agents and bioengineering technology in treatment of pemphigus

SUN Feifei, YANG Baoqi   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2020-12-15 Published:2020-12-04
  • Contact: YANG Baoqi, E-mail: baoqiyang@126.com

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摘要： 天疱疮是一种慢性、复发性表皮内棘层松解性大疱性皮肤病，生物制剂和生物工程技术在天疱疮治疗中发挥一定作用。利妥昔单抗作为一种生物制剂，被国际专家共识推荐为天疱疮一线治疗方案。造血干细胞移植可重建患者的免疫系统，基于前期临床试验确切的疗效，造血干细胞移植已被应用于难治性天疱疮的治疗。调节性T细胞（regulatory T cells，Tregs）在维持自身免疫耐受和避免免疫反应过度损伤中发挥重要作用，应用Tregs过继回输治疗天疱疮前期试验疗效显著。本文综述了利妥昔单抗、干细胞技术以及Tregs过继治疗天疱疮的进展。

关键词: 天疱疮, 利妥昔单抗, 造血干细胞移植, 调节性T细胞

Abstract: Pemphigus is a chronic, recurrent and serious epidermolysis bullous skin disease. Biological agents and bioengineering technology play a certain role in the treatment of pemphigus. Rituximab has been proved to play an important role in the treatment of pemphigus and is recommended as the first-line treatment by guidelines. Hematopoietic stem cell transplantation can rebuild the patient's immune system. Based on the good effect of previous clinical trials, hematopoietic stem cell transplantation has been applied to the treatment of autoimmune diseases including refractory pemphigus. Regulatory T cells (Tregs) play an important role in maintaining self tolerance and avoiding of excessive immune response. Tregs adoptive cell therapy enjoys positive effect in pemphigus and clinical trials are ongoing. The review focuses on the update of Rituximab, hematopoietic stem cell transplantation and Tregs adoptive cell therapy in the treatment of pemphigus.

Key words: pemphigus, rituximab, hematopoietic stem cell transplantation, regulatory T cell