中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (10): 633-636.doi: 10.12144/zgmfskin202110633

• 论著 • 上一篇    下一篇

Gsk-3β、CD82和Axin1在乳房和乳房外Paget病中的表达

魏丽萍1,周文文1,王皓敏2,张士发3   

  1. 1锦州医科大学北部战区总医院研究生培养基地，辽宁沈阳，110016；
    2大连医科大学北部战区总医院研究生培养基地，辽宁沈阳，110016；
    3东北国际医院皮肤科，辽宁沈阳，110623
  • 出版日期:2021-10-25 发布日期:2021-08-31
  • 通讯作者: 张士发，E-mail: zhangshifa_1963@126.com

Expression of Gsk-3β, CD82 and Axin1 in mammary Paget's disease and extramammary Paget's disease

WEI Liping1, ZHOU Wenwen1, WANG Haomin2, ZHANG Shifa3   

  1. 1 Graduate Training Base of Northern Theater General Hospital of Jinzhou Medical University, Shenyang 110016, China; 2 Graduate Training Base of Northern Theater General Hospital of Dalian Medical University, Shenyang 110016, China; 3 Department of Dermatology, Northeast International Hospital, Shenyang 110623, China
  • Online:2021-10-25 Published:2021-08-31
  • Contact: ZHANG Shifa, E-mail: zhangshifa_1963@126.com

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摘要： 目的：检测Gsk-3β、CD82和Axin1在乳房和乳房外Paget病中的表达。方法：采用免疫组织化学方法检测20例乳房Paget病、20例乳房外Paget病及10例正常皮肤组织中Gsk-3β、CD82和Axin1的表达情况。结果：Gsk-3β在乳房Paget病、乳房外Paget病中的表达水平分别为(3.39±1.41)和(2.93±1.37),显著低于正常皮肤组织的(6.50±2.16)，CD82表达水平分别为(6.05±2.14)和(3.90±1.75)，显著低于正常皮肤组织的(10.68±1.11)，Axin1表达水平分别为(2.39±1.49)和(2.77±1.64), 显著低于正常皮肤组织的(5.57±1.72)。Gsk-3β、CD82和Axin1在乳房和乳房外Paget病组织中的表达差异无统计学意义(P>0.05)。结论：Gsk-3β、CD82和Axin1在乳房和乳房外Paget病中低表达，可能与乳房和乳房外Paget病的发病有关。

关键词: 免疫组织化学, Paget病, Gsk-3β, CD82, Axin1

Abstract: Objective: To detect the expression of Gsk-3β, CD82 and Axin1 in mammary Paget's disease (MPD), extramammary Paget's disease (EMPD) and normal skin tissues by immunohistochemical method.Methods: The expression levels of Gsk-3β, CD82 and Axin1 of lesions in 20 MPD cases, 20 EMPD cases and normal skin in 10 controls were detected by immunohistochemical. Results: The expression of Gsk-3β in MPD and EMPD were 3.39±1.41 and 2.93±1.37, which were significantly lower than that in normal skin (6.50±2.16). The expression of CD82 in MPD and EMPD were 6.05±2.14 and 3.90±1.75, which were significantly lower than that in normal skin (10.68±1.11). The expression of Axin1 in MPD and EMPD were 2.39±1.49 and 2.77±1.64, which were significantly lower than that in normal skin (5.57±1.72). There was no significant difference of the expressions of Gsk-3β, CD82 and Axin1 in lesions of MPD and EMPD (P>0.05). Conclusion: The expression level of Gsk-3β, CD82 and Axin1 are decreased in MPD and EMPD, which may be related to the onset of MPD and EMPD.

Key words: immunohistochemistry, Paget's disease, Gsk-3β, CD82, Axin1