中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (6): 373-375.doi: 10.12144/zgmfskin202106373

• 论著 • 上一篇    下一篇

口服头孢克肟治疗早期显性梅毒疗效评价

裴晓燕,杨永华,赵伟,张园,李珍,温晶,田洪青   

  1. 山东第一医科大学附属皮肤病医院(山东省皮肤病医院，山东省皮肤病性病防治研究所)，济南，250022
  • 出版日期:2021-06-15 发布日期:2021-05-27
  • 通讯作者: 田洪青，E-mail: tianhq2006@126.com

Assessment of the efficacy of oral cefixime for the treatment of early symptomatic syphilis

PEI Xiaoyan, YANG Yonghua, ZHAO Wei, ZHANG Yuan, LI Zhen, WEN Jing, TIAN Hongqing    

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Jinan 250022, China
  • Online:2021-06-15 Published:2021-05-27
  • Contact: TIAN Hongqing, E-mail: tianhq2006@126.com

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摘要： 目的：评价头孢克肟对早期显性梅毒的治疗效果。方法：以2018年5月至2020年4月本院性病门诊收治的60例早期梅毒患者作为研究对象。随机分为实验组和对照组。实验组口服头孢克肟治疗，每次100 mg，每日2次，连续15天；对照组给予苄星青霉素治疗，每次240万单位，分双侧臀部肌内注射，每周1次，共2次。比较分析两组患者的治愈率、TRUST转阴率。结果：共治疗患者60例，每组30例，实验组治疗治愈率为83.3%，对照组治愈率为90%，差异无统计学意义（P＞0.05）；实验组和对照组皮疹消退时间分别为(18.17±2.13)天和(17.00±2.68)天，差异无统计学意义(P＞0.05)。不良反应发生率分别为3.3%和10%，差异无统计学意义(P＞0.05)。实验组治疗第6个月、9个月、12个月后的TRUST滴度转阴率（6.7%，40%，53.3%）均高于对照组（3.3%，23.3%，40%），但是差异均无统计学意义（均P＞0.05）。结论：头孢克肟治疗早期显性梅毒疗效、安全性与苄星青霉素相当。

关键词: 梅毒, 梅毒螺旋体, 头孢克肟, 抗生素

Abstract:

Objective: To assess the efficacy of cefixime in the treatment of the patients with early symptomatic syphilis. Methods: The patients with early symptomatic syphilis were enrolled in our hospital from May 2018 to April 2020. The patients were randomly divided into the treatment group and control group. The patients in the treatment group were treated with oral cefixime,100 mg, twice a day for 15 days. The patients in the control group were treated with intramuscular injection of benzathine benzylpenicillin (BPG), 2.4 million units, once a week for 2 weeks. Then the cure rate and negative conversion rate of TRUST titer were compared. Results: Sixty patients were recruited with 30 cases in each group. The cure rate in the treatment group and control group were 83.3% and 90% respectively, with no significant difference (P>0.05). The treatment group and control group were not markedly different in the rash disappearance time (18.17±2.13 days vs 17.00±2.68 days, P>0.05) and the incidence rate of adverse reactions （3.3% vs 10%， P>0.05). In the treatment group, the negative conversion rate of TRUST titer at month 6, month 9, month 12 after the treatment were 6.7%, 40%, 53.3%  respectively, which were 3.3%, 23.3%, 40% in the control group respectively, with no significant differences (Ps<0.05). Conclusion: The efficacy and safety of cefixime are similar to BPG in the treatment of early symptomatic syphilis.

Key words: syphilis, Treponema pallidum, cefixime, antibiotics