中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (4): 217-220.doi: 10.12144/zgmfskin202104217

• 论著 • 上一篇    下一篇

早期隐性梅毒对慢性HIV感染者CD4+T及CD8+T淋巴细胞内Caspase-1/3水平的影响

宋冰冰1,赵金雪2,翁文佳3,高艳青3   

  1. 1首都医科大学附属北京康复医院皮肤科,北京，100041；
    2北京市房山区第一医院皮肤科，北京，102400；
    3首都医科大学附属北京佑安医院皮肤科，北京，100069
  • 出版日期:2021-04-15 发布日期:2021-04-07
  • 通讯作者: 高艳青，E-mail: gyqing2001bj@sina.com

Effect of early latent syphilis on the level of Caspase-1/3 in CD4+T and CD8+T cells in patients with chronic HIV infection

SONG Bingbing1, ZHAO Jinxue2, WENG Wenjia3, GAO Yanqing3   

  1. 1 Department of Dermatology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing 100041,China; 
    2 Department of Dermatology, The First Hospital of Fangshan District, Beijing 102400, China; 
    3 Department of Dermatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
  • Online:2021-04-15 Published:2021-04-07
  • Contact: GAO Yanqing, E-mail: gyqing2001bj@sina.com

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摘要： 目的：明确早期隐性梅毒感染对HIV感染者CD4+T及CD8+T细胞Caspase-1/3水平的影响。方法：流式细胞仪检测18例早期隐性梅毒合并慢性HIV感染者（合并组）以及18例单纯慢性HIV感染者（HIV组）CD4+T及CD8+T细胞内Caspase-1(细胞焦亡标志物)和Caspase-3(细胞凋亡标志物)含量。驱梅治疗6个月后再检测合并组CD4+T及CD8+T细胞内Caspase-1/3含量，与治疗前进行比较。结果：与单纯HIV感染组比较，合并组CD4+T及CD8+T细胞中Caspase-1升高（均P＜0.05），Caspase-3含量无统计学差异（均P＞0.05）。与治疗前比较，合并组驱梅治疗6个月后，CD4+T及CD8+T细胞中Caspase-3明显下降（均P＜0.05），Caspase-1含量治疗前后无统计学差异（均P＞0.05）。结论：合并梅毒螺旋体感染可能影响HIV感染者CD4+T和CD8+T淋巴细胞的焦亡和凋亡。

关键词: 梅毒合并HIV感染, CD4, CD8, Caspase-1, Caspase-3

Abstract: Objective: To determine the effect of early latent syphilis infection on the level of Caspase-1/3 in CD4+T and CD8+T cells in patients with HIV-infected. Methods: The level of Caspase-1, the sign of pyroptosis, and Caspase-3, the sign of apoptosis, in CD4+T and CD8+T cells of 18 patients with early latent syphilis combined with HIV-infected (co-infected group) and 18 patients with chronic HIV infection (HIV group) was detected by flow cytometry. Then the level of Caspase-1/3 in CD4+T and CD8+T cells in the co-infected group after 6 months treatment of syphilis was detected. Results: Compared with HIV group, the level of Caspase-1 in CD4+T cells and CD8+T cells in the co-infected group was higher than that in the HIV group, with significant differences (Ps<0.05), and there was no significant difference of Caspase-3 between the two group (Ps＞0.05). After 6-month-treatment of syphilis, the level of Caspase-3 in CD4+T cells and CD8+T cells decreased in the co-infected group compared with that before treatment, with significant differences (Ps<0.05), and there was no significant differences of the Caspase-1 level before and after treatment (Ps＞0.05). Conclusion: Treponema pallidum infection may affect the pyroptosis and apoptosis of CD4+T and CD8+T lymphocytes in patients with HIV.

Key words: syphilis with HIV co-infection, CD4, CD8, Caspase-1, Caspase-3