中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (11): 836-840.doi: 10.12144/zgmfskin202511836

• 综述 • 上一篇    下一篇

基于多组学技术的特应性皮炎口腔微环境研究进展

金岚彦1,唐欣韵2,周培媚3   

  1. 1成都中医药大学 医学与生命科学学院，四川成都， 610075；2成都市第二人民医院皮肤科，四川成都，610017；3中山大学附属第八医院皮肤科，广东深圳，518033
  • 出版日期:2025-11-15 发布日期:2025-11-11

Research advance on the oral microenvironment of atopic dermatitis based on multi-omics technology

JIN Lanyan1, TANG Xinyun2, ZHOU Peimei3   

  1. 1 School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China; 2 Department of Dermatology, Chengdu Second People's Hospital, Chengdu 610017, China; 3 Department of Dermatology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen 518033, China
  • Online:2025-11-15 Published:2025-11-11

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摘要： 特应性皮炎是一种慢性复发性炎症性皮肤病，表现为反复发作的湿疹样皮损并伴有严重瘙痒，其发病机制十分复杂。目前研究发现口腔微生态失衡通过直接或间接方式参与特应性皮炎发病，近年来，随着多组学技术的发展，口腔微生物群与特应性皮炎之间的关系逐渐受到关注。本综述旨在探讨口腔微生物群在特应性皮炎中的作用，并从宏基因组学、转录组学、代谢组学和蛋白质组学的角度进行综述。

关键词: 特应性皮炎, 口腔微生态, 宏基因组学, 转录组学, 代谢组学, 蛋白质组学

Abstract: Atopic dermatitis is a chronic, recurrent inflammatory dermatological disease characterized by persistent eczematous lesions and severe pruritus. Its pathogenesis is very complex. Recent research has found that oral microecological imbalance participates in the pathogenesis of atopic dermatitis through direct or indirect ways. In recent years, with the development of multi-omics technology, the relationship between the oral microbiota and atopic dermatitis has gradually attracted attention. This review aims to explore the role of the oral microbiota in atopic dermatitis and review it from the perspectives of metagenomics, transcriptomics, metabolomics and proteomics.

Key words: atopic dermatitis, microbiota, metagenomics, transcriptomics, metabolomics, proteomics