中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (4): 292-296.doi: 10.12144/zgmfskin202404292

• 综述 • 上一篇    下一篇

皮肤组织常驻记忆T细胞与炎症性皮肤病复发的研究进展

陈雪琴,宋志强   

  1. 陆军军医大学第一附属医院皮肤科，重庆，400038
  • 出版日期:2024-04-15 发布日期:2024-03-26

Update of skin tissue-resident memory T cells and inflammatory skin diseases recurrence

CHEN Xueqin, SONG Zhiqiang   

  1. Department of Dermatology, the First Affiliated Hospital of Army Medical University, Chongqing 400038, China
  • Online:2024-04-15 Published:2024-03-26

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摘要： 组织常驻记忆T细胞（tissue-resident memory T, TRM）是一种新发现的记忆T细胞亚群。在皮肤感染（如HSV、白色念珠菌、利什曼原虫感染）及皮肤肿瘤性疾病（如黑素瘤和鳞状细胞癌）中，皮肤TRM细胞发挥保护作用，在部分自身炎性皮肤病中皮肤TRM细胞起致病作用。本文对皮肤TRM细胞与炎症性皮肤病复发的研究进展进行综述，特别是银屑病、白癜风、特应性皮炎、固定性药疹、斑秃和额部纤维性脱发。

关键词: 组织常驻记忆T细胞, 银屑病, 白癜风, 特应性皮炎, 固定性药疹, 斑秃, 额部纤维性脱发

Abstract: Tissue-resident memory T (TRM) cells are a newly discovered memory T cell subset. Skin TRM cells play a protective role in skin infections (such as HSV, Candida albicans, and Leishmania infections) and skin neoplastic diseases (such as melanoma and squamous cell carcinoma), and play a pathogeniq role in some autoinflammatory skin diseases. In this paper, we review the update of skin tissue-resident memory T cells and inflammatory skin diseases recurrence, especially psoriasis, vitiligo, atopic dermatitis, fixed drug eruption, alopecia areata and frontal fibrous alopecia.

Key words: TRM, psoriasis, vitiligo, atopic dermatitis, fixed drug eruption, alopecia areata, frontal fibrous alopecia