cured patients with leprosy,IL-10,CD4+CD25+Foxp3+Treg ,"/> Detection of Treg Cells and IL-10 in the Peripheral Blood of the Cured Patients with Leprosy

China Journal of Leprosy and Skin Diseases ›› 2019, Vol. 35 ›› Issue (3): 158-160.doi: 10.12144/zgmfskin201903158

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Detection of Treg Cells and IL-10 in the Peripheral Blood of the Cured Patients with Leprosy

QIU Wenyuan1, LIN Di1, LIN Yueqin1, XIE Caixia1, LAN Feiying1, XIE Longfeng1, LUO Quan2, ZHANG Xibao2   

  1. 1. Guangdong Province Sian Hospital, Dongguan 52300, Guangdong, China; 2. Department of the Skin Laser Guangzhou Institute of Dermatology, Guangzhou 510095, Guangdong, China
  • Online:2019-03-15 Published:2019-04-08
  • Contact: ZHANG Xibao, E-mail: zxibao@126.com

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Abstract: Objective: To detect the level of CD4+CD25+Foxp3+Treg cells and interleulin-10 (IL-10) in the peripheral blood from the cured patients with leprosy in order to explore the mimmune status of them. Methods: The levels of CD4+CD25+Foxp3+Treg in T lymphocyte subgroups and IL-10 in peripheral blood were detected by flow cytometry and ELISA respectilvely in 25 cured patients with leprosy and 20 healthy controls. Results: The level  CD4+CD25+Foxp3+Treg in T lymphocytes and the level of IL-10 in the patients were (7.45±1.43)% and (13.45±3.61) pg/mL, which were higher than those in controls (5.89±1.21)% and (9.23±1.51) pg/mL, with significant differences (P<0.01). There was a significant positive correlation between  CD4+CD25+Treg cells and IL-10 in the cured patients and healthy controls. Conclusion: The level of CD4+CD25+Foxp3+Treg cells and IL-10 in blood serum in the cured patients with leprosy were higher than those in healthy controls, which indicated the cured patients with leprosy may have Immune imbalance.

Key words: cured patients with leprosy')">

cured patients with leprosy, IL-10, CD4+CD25+Foxp3+Treg