China Journal of Leprosy and Skin Diseases ›› 2019, Vol. 35 ›› Issue (5): 284-286.doi: 10.12144/zgmfskin201905284

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Nonbullous pemphigoid: two cases report and literature review

WANG Zhe1,2, SUN Yonghu2, ZHOU Guizhi2, ZHANG Furen1,2   

  1. 1. Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan 250022, China; 2. Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2019-05-15 Published:2019-06-03
  • Contact: ZHANG Furen, E-mail: zhangfuren@hotmail.com

Abstract: Two cases with nonbullous pemphigoid is reported and relative literature is reviewed. One 72-years-old male presented with erythema and papules accompanied by pruritus all over the body for 20 days. On physical examination, there were no visible blisters. The level of eosinophils in blood was increased. Direct immunofluorescence showed a positive linear C3 deposition along the basal membrane band and indirect immunofluorescence showed anti-BP230 antibody and anti-BP180 antibody were  positive. Another 79-year-old female presented with papules all over the body with serve pruritus for 20 days. Physical examination showed obvious scratches without blisters. Eosinophil and anti-BP180 antibody were increased. Both cases were diagnosed as nonbullous pemphigoid. The disease was well controlled after using small dose glucocorticoid.