Abstract: A case of scleromyxedema associated with eosinophilia is reported and relevant literature is reviewed. A 37-year-old male presented with arthralgia for 14 months and generalized waxy papules for 10 months. Histopathology revealed mucin deposition and fibroblast proliferation in the dermis. Laboratory tests demonstrated the high level of monoclonal gammopathy of IgGλ and peripheral eosinophilia. The patient achieved a dramatic improvement of the skin lesions and arthralgia after IVIG treatment combined with systemic corticosteroid and thalidomide for 6 months. 

Key words: scleromyxedema, eosinophilia, immunoglobulins