Abstract: Objective: To detect the changes of indexes in blood and cerebrospinal fluid (CSF) before and after ceftriaxone treatment in HIV-negative patients with asymptomatic neurosyphilis and investigate the significance of prognosis. Methods: The clinical and laboratory test data of 34 patients with asymptomatic neurosyphilis in our department from March 2016 to December 2018 was analyzed, including serum- rapid plasma reagin test (RPR), CSF-leukocytes、CSF-protein amount, CSF-RPR, treponemalpallidumparticleagglutination (TPPA). Results: After 1 course of treatment with ceftriaxone sodium, the median (quartile) of CSF leukocytes and cerebrospinal fluid protein were 0.005 (0.0028, 0.0105) and 0.16 (0.13, 0.245), which were lower than those before treatment 0.0105 (0.0068, 0.022), and 0.3 (0.155, 0.485), with significant differences (Ps<0.005). Compared with before treatment, the blood RPR decreased by ≥4 times at 3 months, 6 months, and 12 months after treatment in 6 (17.65%), 9 (26.47%), and 16 cases (47.06%), respectively. Conclusion: After treatment with ceftriaxone sodium, If the level of leukocyte and protein of CSF decreases and the blood RPR decreases by≥4 times, we can preliminarily predict that the patient is  cured.

Key words: asymptomatic neurosyphilis, laboratory characteristics