Abstract: A 23-year-old male presented with photosensitivity and skin fragility as well as erythema, blistering, erosions on sun-exposed sites. The patient has no similar family history. The blood porphyrin test and antinuclear antibody test were negative. The urine porphyrin test was positive. The 10 exons of UROD gene were sequenced by direct sequencing, and no harmful and pathogenic mutations were found. Histopathological examination revealed subepidermal blisters, glycoprotein deposition of perivascular wall in the superficial dermis. The patient was diagnosed with porphyria cutanea tarda and treated with oral hydroxychloroquine 200 mg twice a day.