Abstract: Objective: To quantitatively evaluate the relationship between environmental PM10 or PM2.5 and allergic skin diseases. Methods: Domestic and international databases were retrieved online, and related literature was collected systematically. Meta-analysis was performed using RveMan 5.3 and Stata 14.2 version, and the sensitivity and subgroup analysis were performed based on the results of heterogeneity. The publication bias was furtherly tested and corrected. Results: A total of 25 studies were included. As an increase of environmental PM10 and PM2.5 in per 10 μg/m3, the combined effect values on allergic skin diseases would be increased by 1.0049 (95% CI: 1.0016-1.0081) and 1.0066 (95% CI: 1.0033-1.0100), respectively. Subgroup analysis showed the combined effect values of PM10 and PM2.5 on atopic dermatitis were 1.0108 (95% CI: 0.9999-1.0219) and 1.0320 (95% CI: 1.0056-1.0590). The combined effect values of PM10 and PM2.5 on eczema were 1.0040 (95% CI: 1.0006-1.0075) and 1.0066 (95% CI: 1.0029-1.0103), and the combined effect value of PM2.5 on urticaria was 0.9994 (95% CI: 0.9852-1.0139). Conclusion: Environmental fine particulate matter is positively associated with allergic skin diseases, and as an increase in concentrations of PM10 and PM2.5 the risk of development of atopic dermatitis and eczema will be elevated.

Key words: particulate matter, PM10, PM2.5, allergic skin disease