Abstract: A 31-years-old female patient presented with widespread erythema and pustules during pregnancy, aggravating for 1 month. The patient had a history of the similar symptoms during pregnancy before 8 years ago and the lesions disappeared spontaneously after delivery. According to the patient's previous medical history, symptoms, physical signs and laboratory examination, the diagnosis of “impetigo herpetiformis” was made. The patient was injected subcutaneously with TNF-α antagonist, supplemented with Minol, Azithromycin anti-inflammatory and topical medication. The lesion was significantly improved after one week treatment.

Key words: impetigo herpetiformis, TNF-α antagonist