Abstract: Cutaneous epithelioid angiomatous nodule (CEAN) is a rare, benign, vascular hyperplasia. It clinically presents as single or multiple, reddish to bluish plaques or nodules, mainly on the trunk and extremities. We reported a 47-year-old female who presented with a nodule on the back for 3 months with mild itching. Biopsy showed the nodule was in the dermis, well-circumscribed, composed of epithelioid cells without heterocyst and a large number of lumen structures were formed. Immunohistochemistry demonstrated positive for CD31, CD34, D2-40, Fli-1, KP-1, Ki-67 (presented a level proliferation index of 20％) and positive lysozyme. The diagnosis of CEAN was made and the nodule was removed with no recurrence for 2 years.