Abstract: A 17-year-old female presented with oral erosions and multiple vesicles all over her body for more than one year. Biopsy showed blisters in subepidermal. DIF showed linear deposition of IgG in the epidermal basement membrane. IIF on salt split skin showed IgG bind on the dermal side. Serologic testing showed positive for Collagen type VII antibody. The diagnosis of epidermolysis bullosa acquisita was made. Prednisone 20mg/d and dapsone 100 mg/d were treated, and the vesicles were obviously subsided. The patient is under follow-up.