Abstract: Fifty-seven patients (47 females, 10 males) with bullous systemic lupus erythematosus in 38 reports were analyzed.  The average age was (26.6±11.8) years. The typical lesions were tense vesicles and bullae on both erythematous patches and normal skin. 64.9%, 61.4% and 40% patients had hematologic abnormalities, renal involvement and polyarthritis respectively. ANA, dsDNA and anti-Smantibodies were positive in 100%, 66.7%, 59.6% patients respectively. 89.1% patients achieved clinical improvements, of whom 23.6% treated with corticosteroid alone and 76.4% treated with corticosteroid and DDS or other immunosuppressants.