Abstract: Objective: To analyze the factors that affect the flap inactivation of oral and maxillofacial tumor with free flap transplantation. Methods: The data of 78 patients with oral and maxillofacial tumors who underwent repair with free flap transplantation in our hospital from October 2014 to October 2019 was retrospectively analyzed. The patients were divided into the flap inactivation group and the flap survival group. Measurement data was compared in the two group by independent sample t test, count data were analyzed by χ2 test, and multivariate analysis was performed by logistic regression analysis. Results: In 78 patients, 11 (14.10%) had flap deactivation, of which 10 (90.91%) had partial deactivation. The results of univariate analysis showed that there were significant differences between the two groups in the incidence of diabetes mellitus, lymph node metastasis, oral infection and the level of albumin, total protein and fibrinogen (Ps<0.05). Multivariate analysis showed that diabetes, oral infection, and elevated fibrinogen were the risk factors for flap inactivation (Ps<0.05). Conclusion: The factors influencing flap inactivation with free flap transplantation for the reconstruction of oral and maxillofacial tumor include diabetes mellitus, oral infection and fibrinogen level. 

Key words: free flap transplantation, oral and maxillofacial tumor, flap inactivation, influencing factors