China Journal of Leprosy and Skin Diseases ›› 2021, Vol. 37 ›› Issue (4): 208-211.doi: 10.12144/zgmfskin202104208

• Original Articles • Previous Articles     Next Articles

Meta-analysis of the association of bullous pemphigoid with malignancy

LI Yun1, ZHU Qinghuan2, LIAO Chifeng3, YANG Meng2,4, HUANG Yaohui4, PAN Yanbin4, LI Jianmin4   

  1. 1 Department of Dermatology, The First Affiliated Hospital of the Army Medical University, Chongqing 400038, China; 2 Department of Dermatology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China; 3 Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei 230032, China; 4 Department of Dermatology, The Third Affiliated Hospital of Guangxi Medical University, Nanning 530031, China
  • Online:2021-04-15 Published:2021-04-07
  • Contact: YANG Meng, E-mail: ymcomcn@126.com

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Abstract: Objective: To determine the association of bullous pemphigoid (BP) with malignancy. Methods: The studies of BP and malignancy in Cochrane Library, PubMed, Embase, Wanfang, CNKI, and VIP database were searched. Meta-analysis was carried out by Stata 12.0 software. Results: A total of 1549 studies were initially searched, in which 10 randomized controlled trial were analyzed. The results showed that the risk of total malignancy and hematologic malignancy in the BP group were higher than that in the control group (Ps<0.05), but there was no significant difference in the incidence of solid malignancy between the two groups (P=0.07). Conclusion: There is an association between BP and malignancy, but more prospective studies are needed to confirm the association.

Key words: BP, hematologic malignancy, solid malignancy, meta analysis