Abstract: A 70-year-old male presented with polymorphic erythema and papules without blisters all over his body with pruritus for more than 3 months. Biopsy showed mild intercellular edema in the spinous layer, lymphocyte and eosinophilic granulocyte infiltration around superficial dermal vessels. Direct immunofluorescence showed negative IgG, C3, IgM and IgA between epidermal cells and basement membrane. Indirect immunofluorescence showed positive pemphigoid circulating antibody IgG with the titer of 1:40. Human salt-split skin indirect immunofluorescence showed positive circulating antibody IgG on epidermis side. The patient was diagnosed as nonbullous pemphigoid, and was given niacinamide, tetracycline combined tripterygium glycosides orally, accompany with topical halometasone cream. The lesions basically disappeared after 2 months.