Abstract: Objective: To assess the therapeutic effect of single hair follicle transplantation (FUE) combined with phototherapy in the treatment of refractory vitiligo with white hair. Methods:The  refractory vitiligo patients with white hair from June 2019 to December 2020 were collected. A single hair follicle was transplanted into the vitiligo lesion, then 308 excimer laser followed, initial dose of 50 mJ, 2-3 times a week, 3 months for a course of treatment. Results: Twenty patients including 25 lesions were treated after treatment for 3 months. Of 25 lesions, pigment recovery around transplanted hair follicles in 19 lesions, including 2 cured, 17 markedly effective. A total of  showed black hair growth in 24 lesions. Conclusion: The therapy of single hair follicle transplantation (FUE) combined with phototherapy is effective in the treatment of refractory vitiligo with white hair. 

Key words: single hair follicle transplantation, refractory vitiligo