China Journal of Leprosy and Skin Diseases ›› 2022, Vol. 38 ›› Issue (1): 34-36.doi: 10.12144/zgmfskin202201034

• Clinical Researches • Previous Articles     Next Articles

TNF-α antagonist combined with immunoglobulin in the treatment of herpes virus-related chronic relapsing erythema multiforme: a case report

WANG Na, LIU Hong, WU Weizhi, ZHANG Zhaoxia, ZHOU Guizhi, SHI Zhongxiang, ZHANG Furen   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venerology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2022-01-15 Published:2021-11-01
  • Contact: ZHANG Furen, E-mail: zhangfuren@hotmail.com

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Abstract: We report a case of herpes simplex virus-related chronic relapsing erythema multiforme (EM) treated with adalimumab and immunoglobulin and review the related literature. A 9-year-old boy presented with repeated lip erosions for 15 months, and erythema all over the body for 8 months. Dermatological examination showed lip erosion, scattered dark red patches on back and limbs, with loosing blisters on the local periphery. The featrue of biopsy was consistent with EM, and the herpes simplex virus type I IgG titer was 444.72 RU/mL. The diagnose of erythema multiforme induced by herpes simplex virus was made. The patient was treated with valaciclovir, adalimumab and immunoglobulin, and the lesions subside after treatment for 2 weeks, and herpes simplex virus type I IgG titer was decreased significantly.

Key words: erythema multiforme, herpes simplex virus, tumor necrotic antagonist