Abstract: A 57-year-old woman presented with a slowly growing, smoothsurfaced masss on the right third finger, and the nail dehisced gradually. Histopathology of the mass showed that accompanied by fibroblasts and collagen fiber bundles of cross-trending. Histopathology of right third finger double-layered nails showed the nail plate was flat with a large amount of subungual keratinization, epidermal hyperkeratosis, and focal parakeratosis. The diagnosis of nail loss secondary to periungual fibroma was made and the lesions were excised.