Abstract: Integrin α3β1 is an important cell adhesion molecule, which maintaining skin structural homeostasis. Integrin α3β1 can interact with different ligands in the extracellular matrix, leading to spatio-temporal activation of downstream pathway which constitutes complex skin homeostasis network, regulat the extracellular microenvironment directly or indirectly, mediate cell proliferation, differentiation, adhesion and migration, and finally participate in the basement membrane development, wound healing, and skin carcinogenesis. The update of the pathogenesis of integrin α3β13 in skin diseases is reviewed in this artical.

Key words: integrin, basement membrane maturation, wound healing, tumor metastasis