Abstract: Psoriasis is a chronic recurrent inflammatory skin disease, which often recurs at the remission site of the primary skin lesions. Tissue resident memory T cells (TRM) can reside in the skin for a long time. In recent years, many studies have shown that TRM plays a crucial role in psoriasis recurrence and effective inhibition of TRM may be the key to control psoriasis recurrence. However, the anti-injury and anti-apoptotic characteristics of TRM make it difficult to control the recurrence. In this paper, we reviewed the production and residence of cutaneous TRM and the relationship between TRM and psoriasis recurrence.

Key words: recurrence of psoriasis, tissue resident memory T cells