Abstract: Recent studies show that immune checkpoints (CTLA-4, PD-1, TIM-3, TIGIT and LAG-3) are expressed on the surface of immune cells, and are associated with the proliferation, invasion, metastasis of tumor cells. Immune checkpoint inhibitors have been widely used in the clinical treatment of skin tumors and have achieved remarkable efficacy. In this review, we discuss the mechanisms and clinical applications of different kinds of immune checkpoints in skin tumors.

Key words: immune checkpoints, immune checkpoints inhibitors, skin tumors