Abstract: Eosinophilic Granulomatosis with Polyangiitis (EGPA) is an autoimmune disease characterized by adult-onset asthma, peripheral blood and tissue eosinophilia, and microvasculitis. We report a patient with a history of asthma and chronic sinusitis, a significant increase in peripheral blood eosinophils, and histopathologic findings of dermal eosinophile infiltration, necrotizing small vasculitis, and extravascular granuloma, granular deposition of C3 in the basement membrane zone and vascular wall of the superficial and middle dermis. The therapy of oral prednisone (25 mg/day) and topical halometasone cream was given, and the rash and bulla gradually subsided.

Key words: eosinophilic granulomatosis with polyangiitis, allergic rhinitis, asthma