China Journal of Leprosy and Skin Diseases ›› 2023, Vol. 39 ›› Issue (8): 571-575.doi: 10.12144/zgmfskin202308571

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Carbamazepine-induced DRESS syndrome with HLA-A*31:01 gene positive

LIU Jiayi1，2, ZHAO Qing2, WU Weizhi2, ZANG Xiao2, WANG Weiwei2, SUN Lele2, ZHOU Guizhi2, YANG Qing2, LIU Hong2, ZHANG Furen1,2   

  1. 1 Shandong University, Jinan 250012, China; 2 Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2023-08-15 Published:2023-07-19

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Abstract: Objective: To clarify the diagnosis and identify sensitizing drugs in a patients with eosinophilia and systemic symptoms (DRESS) syndromedrug hypersensitivity syndrome possibly induced by carbamazepine. Methods: Clinical data and the peripheral blood of the patient were collected and the peripheral blood mononuclear cells (PBMCs) were extracted. HLA testing and lymphocyte transformation test (LTT) were performed. Results: The HLA testing indicated that the patient carried the HLA-A*31:01 allele. The LTT results of this patient showed that lymphocytes proliferated after carbamazepine stimulation. Conclusion: Based on the clinical manifestations, HLA testing and LTT results, the patient was diagnosed as the DRESS syndrome induced by carbamazepine.

Key words: DRESS, carbamazepine, HLA-A*31:01