Abstract: Objective: To identify the fungal species of patients with superficial fungal infections in our hospital and the sensitivity to antifungal drugs. Methods: Patients with superficial fungal infections in our hospital from July 2019 to December 2021 were collected for microscopic examination, culture strain isolation, and molecular biological identification. For dermatophytes, the sensitivity of the tested strains to 7 common antifungal drugs was detected according to the M38-A2 protocol of the Clinical and Laboratory Standards Institute (CLSI) in the United States; for yeasts, a drug sensitivity test kit was used to detect the sensitivity of the tested strains to 5 common antifungal drugs. Results: Among 2143 suspected patients with superficial fungal infections, 1157 cases were positive by microscopic examination. Among them, performed on 33 isolated dermatophyte strains and 23 Candida strains. The results showed that among the 33 dermatophyte strains, Trichophyton rubrum was the dominant species (27, 81.8%); among the 23 Candida strains, Candida parapsilosis and Candida albicans were the most, accounted for 34.78% and 26.09% respectively. The drug sensitivity test of 21 Candida strains showed that amphotericin B had the highest sensitivity; the sensitivity results of 22 Trichophyton rubrum strains showed that the MIC of ciclopirox, griseofulvin, itraconazole, voriconazole, fluconazole, terbinafine, and posaconazole were all at low levels, and the geometric mean MIC of voriconazole was the lowest (0.0096 mg/L). Conclusion: The main pathogens of superficial infections are Trichophyton rubrum, Candida parapsilosis, and Candida albicans. Candida is sensitive to amphotericin B, and Trichophyton rubrum is sensitive to voriconazole.

Key words: Candida, dermatophytes, sensitivity to antifungal drugs