China Journal of Leprosy and Skin Diseases ›› 2025, Vol. 41 ›› Issue (5): 374-376.doi: 10.12144/zgmfskin202505374

• Case Reports • Previous Articles     Next Articles

Talaromyces marneffei infection in a HIV antibody-negative patient: a case report

SUN Lin1,2, WU Wenjie1,2, DA Meihong2, JIANG Hao3, WANG Fei2   

  1. 1 School of Medicine, Southeast University, Nanjing 210003, China; 2 Department of Dermatology, Zhongda Hospital Southeast University, Nanjing 210009, China; 3 Department of Dermatology, Xuyi People's Hospital, Huaian 211799, China
  • Online:2025-05-15 Published:2025-05-15

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Abstract: Talaromyces marneffei infection is a rare deep fungal disease and an opportunistic pathogen, mainly infects immunocompromised individuals such as those with HIV positive. We report a case of HIV antibody-negative patient with general erythema and crust, diffuse bald scalp. The patient was diagnosed with Talaromyces marneffei infection by skin biopsy, fungal culture, and next-generation sequencing technology. Antifungal treatment was administered, and the skin lesions of the patient gradually subsided. There was no recurrence during the 3-month follow-up.

Key words: Talaromyces marneffei infection, HIV negative, T cell immunodeficiency