Abstract: We herein report a rare case of Sj?gren's syndrome (SS) complicated with suppurative parotitis and nontuberculous mycobacterial (NTM) infection. The patient was a middle-aged female with a 6-year history of SS and chronic recurrent parotitis. She was admitted due to suppurative parotitis that was unresponsive to conventional antibiotic therapy. NTM was detected in the pus from the lesion. According to the clinical guidelines for the diagnosis and treatment of NTM infection and the results of drug susceptibility testing, anti-infective therapy with clarithromycin combined with amikacin and moxifloxacin was administered. Since the parotid lesion was localized, incision and drainage of the left parotid abscess was performed. After 2 weeks of continuous treatment, the wound healed, parotid swelling resolved completely, and her facial appearance returned to normal.

Key words: Sj?gren's syndrome, suppurative parotitis, nontuberculous mycobacteria infection